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476025 
Journal Article 
Genetics of autoimmune diseases - disorders of immune homeostasis 
Gregersen, PK; Behrens, TW 
2006 
1 
Nature Reviews. Genetics
ISSN: 1471-0056
EISSN: 1471-0064 
7 
12 
917-928 
English 
In the past few years, our extensive knowledge of the mammalian immune system and our increasing ability to understand the genetic causes of complex human disease have opened a window onto the pathways that lead to autoimmune disorders. In addition to the well-established role of genetic variation that affects the major histocompatibility complex, a number of rare and common variants that affect a range of immunological pathways are now known to have important influences on the phenotypic diversity that is seen among autoimmune diseases. Recent studies have also highlighted a previously unanticipated interplay between the innate and adaptive immune system, providing a new direction for research in this field. 
systemic-lupus-erythematosus; regulatory t-cells; lymphoid tyrosine; phosphatase; cyclic citrullinated peptide; immunological; self-tolerance; transcription factor foxp3; genome-wide association; toll-like receptors; binding lectin mbl; rheumatoid-arthritis