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HERO ID
4774763
Reference Type
Journal Article
Title
Syntheses, Crystal Structures and Urease Inhibition of Two Manganesen(III) Complexes with Bis-Schiff Bases
Author(s)
Li Yun-Tong; Dong Jing-Wen; Lu Yao; Gu Yi-Tong; Shang Chao-Nan; Liu Fu-Yao; Xin Yu; Jing Chang-Ling; You Zhong-Lu
Year
2018
Is Peer Reviewed?
Yes
Journal
Chinese Journal of Inorganic Chemistry / Wu Ji Hua Xue Xue Bao
ISSN:
1001-4861
Volume
34
Issue
6
Page Numbers
1192-1198
DOI
10.11862/CJIC.2018.147
Web of Science Id
WOS:000437814000024
Abstract
A bis-Schiff base N,N'-bis(3,5-difluorosalicylidene)-1,3-diaminopropane) (H2L) was prepared. Reaction of H2L and manganese acetate with ammonium thiocyanate or sodium azide in methanol gave complexes [MnL(NCS)(OH2)] (1) and [MnL(mu(1),(3)-N-3)](n) (2), respectively. H2L and the complexes were characterized by elemental analysis, IR spectra, H-1 NMR spectra, and the crystal structures of the complexes were analyzed by single crystal X-ray diffraction. The Schiff base ligand coordinates to the Mn atom through the imino nitrogen and phenolate oxygen. The thiocyanate ligand coordinates to the Mn atom through the nitrogen atom, and the azide ligand coordinates to the Mn atom, with a bridging mode, through two terminal nitrogen atoms. In both complexes, the Mn atoms adopt octahedral coordination. The Schiff base and the complexes were tested for their Jack bean urease inhibitory activities. For complex 1, the inhibition rate at concentration of 100 Rmol " on the urease is (52.0 3.1)%, and the IC50 value is (81.0 +/- 3.7) mu mol L-1 While for complex 2, it has no activity against the urease. Molecular docking study of complex 1 was performed to study the inhibition.
Keywords
Schiff base; manganese(III) complex; crystal structure; urease inhibitor
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LitSearch: January 2008 - August 2018
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