US EPA

4795802 

Journal Article 

NIOSH Skin Notation (SK) Profile: Ethyl p-nitrophenyl phenylphosphorothioate (EPN) (CAS No. 2104-64-5) 

Hudson, NL; Dotson, GS 

2017 

Although the mathematical model did not predict EPN to be absorbed through the skin following dermal exposure, toxicokinetic data on cats [Abou-Donia et al. 1983a; 1983d, 1983e], data from acute toxicity studies in rats [Gaines 1969], rabbits [Hodge et al 1954], and cats [Abou-Donia et al. 1983b], and findings in subchronic studies of hens and cats [Abou-Donia et al. 1983b, 1983c] indicate EPN is absorbed through skin, is systemically available, and has the potential to cause systemic effects, including fatality, following dermal exposure. No in vivo or in vitro studies of humans or animals that evaluated the potential of EPN to cause direct skin effects or skin sensitization were identified. Therefore, on the basis of these assessments, EPN is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for EPN previously issued by NIOSH and other organizations. The equivalent dermal designation for EPN, according to the Globally Harmonized System (GHS) for Classification and Labelling of Chemicals, is Acute Toxicity Category 1 (Hazard statement: Fatal in contact with the skin) [European Parliament 2008].