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4808779 
Journal Article 
Study of cobalt ferrite nanosuspensions for low-frequency ferromagnetic hyperthermia 
Kashevsky, BE; Agabekov, VE; Kashevsky, SB; Kekalo, KA; Manina, EYu; Prokhorov, IV; Ulashchik, VS 
2008 
1 
Particuology
ISSN: 1674-2001 
6 
5 
322-333 
WOS:000260657100005 
High-coercive cobalt ferrite nanoparticles were synthesized and studied for magnetic hyperthermia by direct injection of their suspension into a tumor and application of a strong audio-frequency magnetic field for heating. Physical (dynamic magnetic hysteresis and heat generation in both liquid and solid dispersions), biological (toxicity and penetration of particles in therapeutic quantities into mouse tumor tissue) as well as other properties of the particles were studied. A model was developed to describe the magnetodynamics in suspensions of magnetic nanoclusters with an account for both Brownian and regular rotations, to provide understanding of observed phenomena. The experimental and theoretical techniques developed have formed a basis for controllable synthesis of the magnetic nanoparticles for low-frequency heat generation in medical and other applications. (C) 2008 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved. 
Cobalt ferrite nanoparticles; Magnetic suspensions; Dynamic magnetic hysteresis; Medical hyperthermia