Figueroa-Valverde, L; Diaz-Cedillo, F; Rosas-Nexticapa, M; Garcia-Cervera, E; Pool-Gomez, E; Lopez-Ramos, M
In this study, three naphthol derivatives were synthesized. The first :stage, involved preparation of 34[243-hydroxy-13-methyl-6,7,8,9,11 12 13,14,15,16-decahydro,-cyclo- penta[a]phenanthren-17-ylidetteamino)-ethylamino]-(3-hydroxy-naphialen-2-y1)..4nethyl]-1,7,7-trimethyl-bicyclo[2.2.Theptan-2-One (4) by the reaction of 1,7,7-trimethyl-bicyclo[22.1]heptan-2--ohe (1) with 11--(2-aminO-ethylimino)13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-,61-1-cycloprenta[a]phenatithren-3-ol (2) and 2-hydrOxy-l-naphthaldehyde (3) nsing prolirte as catalyst The second stage was achieved by the reaction of Compund 1 With 1 [(2-amino-ethylamino)-phenyl-Methyl] -naphthalen-2-ol to form the compounc11-{phenyl-R-(1,7,7-trunetliy.1-bicyclo[2:11]hept-2-ylifileneammo)ethyl-ammo],inethyl)napnalen-2-ol (b) using boric acid as catalyst The third stage Was achieved by the synthesis of N43-cir-hydroxy-10A,12a-dirnethYl-2 2,3a,3bA5,10,10aJOb,11,12,12-adodecallydro-111-7-oxa-8-azadicyClopenta[a,h]plietianthren-1-ylethynylamino)-3-(3-hydroxy-naphtalen-2-y1)-propyll-succinainiencid 5-ntetboxy-phenylester (9), using the three, components system (2thydroxy-r-tinphthaldety4e, 4-ally14Jitethoxyphetyl 4- [(2-aminoethyl)amino] +oxobutarioate anddanatol) The structure of all compounds obtained was confirtnedby elemental analysis, spectroscopy and spectrometry data.