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4884047 
Journal Article 
Anti-insulin resistance effects of diarylheptanoids and flavonoids from Myrica rubra leaves 
Chen, P; Yang, CHsu; Yao, JY; Xia, J; Zheng, W; Wu, X; Li, J; Wang, Y; Wang, GH; Xu, J; Luo, L; Chen, YH 
2018 
1 
Minerva Biotecnologica
ISSN: 1120-4826 
30 
1 
1-6 
WOS:000429096200001 
BACKGROUND: Some human metabolic enzymes, including AMPK, Acetyl-CoA carboxylase, E1 ubiquitin activating enzyme, glycogen synthase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are key indexes of metabolic disorders caused by type II diabetes. These enzymes are important for insulin regulation and stability maintenance of the human body.



METHODS: We analyzed the effects of (2R)-3',4"-epoxy-2-hydroxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl) heptan-3-one (compound 1), myricanol (compound 2), myricetin (compound 3) and myricitrin (compound 4) extracted from Myrica rubra leaves on type II diabetes.



RESULTS: We discovered that 2R)-3',4"-epoxy-2-hydroxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl) heptan-3-one (compound 1) was the best compound to relieve metabolic disorders caused by type II diabetes.



CONCLUSIONS: We concluded that the four compounds promoted glycogen synthesis and improved the overall effectiveness of carbohydrate metabolism. 
Myrica; Motor activity; Diabetes mellitus, type 2; Metabolic diseases