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491688 
Journal Article 
Remarkable stabilization of duplex DNA containing an abasic site by non-nucleosidic phenanthroline and pyrene building blocks 
Langenegger, SM; Haner, R 
2005 
Yes 
ChemBiochem
ISSN: 1439-4227
EISSN: 1439-7633 
WILEY-V C H VERLAG GMBH 
WEINHEIM 
6 
5 
848-+ 
English 
15776408 
WOS:000229171800015 
Abasic sites represent a frequently occurring lesion in DNA. If not repaired, such lesions can lead to mutations or cell death. Stabilization of DNA containing abasic sites is investigated as a therapeutic approach for the treatment of cancer. Non-nucleosidic phenanthroline and pyrene derivatives were found to have a profound stabilizing effect (&UDelta; T-m = 8° C) on DNA missing a nucleobase. 
abasic sites; DNA; phenanthroline; pyrene; stacking interactions; recognition; repair; oligonucleotide; conformation; stability; biology