Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
4929236
Reference Type
Journal Article
Title
Synthesis of Phosphoester Compounds Using Lactic Acid for Encapsulation of Paclitaxel
Author(s)
Takeuchi, I; Mikuni, R; Makino, K
Year
2018
Is Peer Reviewed?
Yes
Journal
Anticancer Research
ISSN:
0250-7005
EISSN:
1791-7530
Volume
38
Issue
6
Page Numbers
3401-3406
Language
English
PMID
29848689
DOI
10.21873/anticanres.12607
Web of Science Id
WOS:000449934200022
Abstract
BACKGROUND/AIM:
In the use of paclitaxel, side-effects caused by itself or solubilizing agents have become a major obstacle. In this study we aimed to synthesize biocompatible and degradable compounds for micelles to be used as carriers for paclitaxel.
MATERIALS AND METHODS:
Methoxypolyethylene glycol-lactate was obtained from methyl lactate and methoxypolyethylene glycol having a molecular weight of 350. Monoalkoxy phosphoryl chlorides were obtained from phosphoryl chloride and four kinds of linear alcohols. Then, four kinds of alkyl di(methoxypolyethylene glycol-lactate) phosphates were obtained from them.
RESULTS:
The results of 1H NMR spectroscopy showed that alkyl di(methoxypolyethylene glycol-lactate) phosphates were successfully synthesized. When 1-dodecanol, 1-hexadecanol, 1-octadecanol, and 1-eicosanol were used as side chains, the yields were 73.5±4.2, 69.1±3.6, 72.2±2.8, and 71.8±3.7%, respectively. The spectrum of 31P NMR suggested the existence of optical isomers.
CONCLUSION:
Four kinds of phosphoester compounds for micelle preparations were synthesized using lactic acid.
Tags
OPPT
•
Fatty Alcohols
Literature Search
Human Health
PubMed (private)
PFAS
•
PFAS 150
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
11:1 Fluorotelomer alcohol
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity