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4931069 
Journal Article 
Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels 
Marien, K 
1996 
Yes 
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 
104 
11 
1230-1236 
WOS:A1996VX74000022 
Domoic acid has been found in razor clams (Siliqua patula) and dungeness crabs (Cancer magister) in Washington State and elsewhere on the West Coast of the United States. Due to toxic effects associated with domoic acid exposure, an effort has been made to establish tolerable domoic acid levels in crabs and clams obtained from commercial han first and sale and from individual recreational harvesting. To accomplish this, the amount of dams and crabs consumed by populations of concern was determined, a tolerable daily intake (TDI) was developed for individuals most sensitive to effects of this compound, and the TDI was equated with consumption patterns to determine tolerable dam and crab domoic acid levels. Results indicate that the primary health effects associated with domoic acid toxicity can be averted in populations of concern and for others consuming crabs or clams less frequently (or in lesser quantity) if domoic acid contaminant concentration does not exceed 30 mg/kg in the hepatopancreas and viscera of dungeness crabs or 20 mg/kg in clams. 
clam; consumption survey crab; domoic acid; excitatory amino acid; neurotoxicity; older adults; tolerable daily intake