US EPA

4935815 

Journal Article 

Propionate pathway metabolites as regulators of fatty and dicarboxylic acid oxidation in liver mitochondria 

Fedotcheva, NI; Gessler, NN; Anikeeva, SP; Ignat'ev, DA; Bykhovskiĭ, VYa; Kondrashova, MN 

1993 

1 

Biochemistry (Moscow)
ISSN: 0006-2979
EISSN: 1608-3040 

58 

4 

387-391 

English 

WOS:A1993MF73800011 

is translation of 4923716 [Metabolites of the propionate pathway as regulators of fatty and dicarboxylic acid oxidation in liver mitochondria]

The functioning of the propionate pathway of oxidation substrate metabolism was studied in the norm and under vitamin B-12 deficiency. The pathway was shown to play an important role in the proper oxidative process since its inhibition in B-12-deficient animals results in a decrease in respiration, palmitoylcarnitine and succinate oxidation rates, and coupling of oxidative phosphorylation. Succinate, the end product of the propionate pathway, normalizes respiration and restores the rate of palmitoylcarnitine oxidation in B-12-deficient animals, showing its crucial role in the propionate pathway. In vivo propionate inhibits, whereas methyl malonate stimulates, palmitoylcarnitine respiration, but only in control animals. In B-12-deficient animals the sensitivity to these metabolites is decreased. 

propionate; methyl malonate; succinate; oxidizing activity; liver mitochondria