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4938985 
Journal Article 
Excretion of zopiclone into breast milk 
Matheson, I; Sande, HA; Gaillot, J 
1990 
Yes 
British Journal of Clinical Pharmacology
ISSN: 0306-5251
EISSN: 1365-2125 
30 
Aug 1990 
267-271 
English 
2206788 
WOS:A1990DT09000015 
IPA COPYRIGHT: ASHP The excretion of zopiclone into breast milk was studied in 12 lactating women (mean age 32 yr) in the early postpartum period following oral administration of a single 7.5 mg zopiclone tablet. The milk/plasma AUC ratio of the drug was 0.51+-0.09. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in nonpregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. Assuming a daily milk intake of 0.15 l/kg and 100% absorption, the average infant dose of the drug in milk would be 1.4% of the weight adjusted dose ingested by the mother. 
Toxicology Abstracts; Excretion; zopiclone; Tablets; Oral administration; Infants; Pharmacokinetics; Postpartum; Breast milk; X 24320:Food Additives & Contaminants