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4992952 
Journal Article 
Effects of organochlorine compounds on lipid catabolism of foetal rat liver mitochondria and microsomes 
Pollak, JK; Harsas, W 
1982 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
Springer-Verlag 
Bull Environ Contam Toxicol. 
28 
3 
313-318 
English 
7082871 
The toxicity and action of organochlorines on intermediary metabolism is not well understood. Because of their lipid solubility, organochlorines in general are thought to interfere with lipid metabolism or membrane structure. In an attempt to carry out a systematic study, three different types of organochlorines were selected to investigate their effect on lipid metabolism. The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), the insecticide and acaricide N'-(4-chloro-2-methyl-phenyl-N,N-dimethylforamidine-HC1 (chlordimeform 80 SP), and the industrial solvent 1,1,1-trichlorethane were chosen. The test-systems chosen for the present study were preparations of foetal rat liver mitochondria and microsomes. The catabolism of endogenous triglycerides in these organelles of foetal liver is markedly greater than that in liver mitochondria and microsomes of later developmental ages. Comparisons were made between lipid catabolism of foetal rat liver mitochondria and microsomes after the pregnant rats had been exposed to 2,4,5-T or chlordimeform 80 SP or 1,1,1-trichoroethane. Pregnant rats injected with NaCl were used as controls. 
2,4,5-Trichlorophenoxyacetic Acid/pharmacology; Animals; Chlorphenamidine/toxicity; Hydrocarbons, Chlorinated/pharmacology; In Vitro Techniques; Lipid Metabolism; Liver/embryology; Microsomes, Liver/metabolism; Mitochondria, Liver/metabolism; Phospholipids/metabolism; Pregnancy; Proteins/metabolism; Rats, Inbred Strains; Trichloroethanes/pharmacology; 113C650IR1; 9Q963S4YMX; GXA8FP6Y9C