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4993991 
Journal Article 
Biological and pharmacological properties of flubendazole 
Thienpont, D; Vanparijs, O; Niemegeers, C; Marsboom, R 
1978 
1 
Arzneimittel-Forschung
ISSN: 0004-4172
EISSN: 1616-7066 
28 
4 
605-612 
English 
581937 
Methyl[5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl] carbamate (flubendazole) the p-fluor analogue of mebendazole, was investigated on 19 types of nematode and cestode infections occurring naturally or induced experimentally in 7 animal species: rat, mouse, chicken, turkey, pig, dog and sheep. Flubendazole was administered orally or mixed into the feed. In either case, the substance was well tolerated. Nausea, vomiting or diarrhoea were not observed. Flubendazole appeared to be active against mature and immature nematodes such as Trichinella spiralis, Syngamus trachea and Ascaris suum. The gastrointestinal nematodes of the sheep responded to one single administration. In the dog, pig and turkey, however, repeated doses were necessary to achieve a 100% efficacy. Trichuris vulpis, Trichuris muris and Trichinella spiralis were equally sensitive to flubendazole. The immature cestode forms Cysticercus fasciolaris and hydatids of Echinococcus granulosus in the mouse were controlled both prophylactically and curatively by repeated oral administration. Toxicity studies were performed in various laboratory animals. The LD50 in acute toxicity tests was above 2560 mg/kg for all animal species. In the chronic toxicity studies in the rat and dog, no side-effects were observed, neither clinically nor histopathologically. The teratological results in the rat and rabbit were normal, as were the peri- and postnatal effects and fertility experiments in the rat. 
flubendazole; adverse drug reaction; animal experiment; animal food; cestode; chicken; controlled study; dog; dose response; drug efficacy; drug response; drug tolerance; drug toxicity; embryo; embryotoxicity; in vitro study; infection; intoxication; large intestine; ld 50; methodology; mouse; nematode; normal value; oral drug administration; rat; sheep; small intestine; subcutaneous drug administration; swine; teratogenesis; therapy; turkey (bird); Animals; Benzimidazoles; Chickens; Dog Diseases; Dogs; Embryo; Female; Fertility; Helminthiasis; Helminthiasis, Animal; Male; Mebendazole; Mice; Pregnancy; Rats; Rodent Diseases; Sheep; Sheep Diseases; Swine; Swine Diseases; Teratogens; Turkeys