Health & Environmental Research Online (HERO)


Print Feedback Export to File
5015163 
Technical Report 
Scaled-up synthesis: Salts of carfentanil and remifentanil 
Walz, AJ; Hsu, FL 
2017 
Edgewood Chemical Biological Center 
Aberdeen Proving Ground, MD 
AD1039337 
18 
English 
4-Anilidopiperidines are potent synthetic opioids that are employed as analgesics worldwide. Janssen, Van Daele, Niemegeers, Janssens, and their coworkers have produced many potent and clinically useful compounds.2–5 A potent, short-acting analog was later developed by Feldman et al.6 Some of these analgesics have been prescribed as potent sedatives for large animals (carfentanil) and humans (remifentanil).

A few of the pharmaceutically relevant salts of these compounds are carfentanil oxalate, carfentanil citrate, remifentanil oxalate, and remifentanil hydrochloride. The work presented demonstrates the multigram syntheses of these four salts. 
• Chloroform Combined (current)
     Chloroform (original)
          References: 2000-2018
               ToxNet