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501576 
Journal Article 
Abstract 
Cognitive development and low-level lead exposure in poly-drug exposed children 
Min, M; Singer, L; Minnes, S; Kirchner, HL; Nelson, S 
2008 
1 
Neurotoxicology and Teratology
ISSN: 0892-0362
EISSN: 1872-9738 
30 
3 
249 
English 
WOS:000257303100033 
is summary of 501577 Cognitive development and low-level lead exposure in poly-drug exposed children
Clinical studies have shown that lead exposure may influence intellectual function and behaviors in children. These findings have been suggested as evidence of organic bases in the pathophysiology of attention deficit hyperactivity disorder (ADHD). This study was aimed to determine whether lead exposure could be a risk factor in ADHD comparing blood lead levels between ADHD patients and healthy controls. We also investigated the correlation between blood lead level and behaviors and cognitive functions in ADHD patients. ADHD patients and healthy controls were aged 6 12, twenty one for each group. We assessed intelligence and behavioral problems by means of Abbreviated Korean Educational Development Intelligence Scale for Children, Abbreviated Conners Rating Scale-Revised, and Korean Child Behavior Cheklist (CBCL) in both groups. We also measured blood lead levels in both groups. We evaluated cognitive functions using Computerized Performance Test, Stroop Test, Matching Familiar Figure Test, and Trail Making Test B in ADHD patients. The results were as follows. 1) There were no differences in the blood lead levels between ADHD patients and controls (2.29±0.94~tg/dl and 1.91±0.89~tg/dl, respectively). 2) There was negative correlation between blood lead levels and scores of school performance subscale of CBCL in ADHD patients (Pearson correlation coefficient 0.419, p 0.049). 3) There were no correlations between blood lead levels and scores of cognitive functions in ADHD patients. We could not demonstrate that the lead exposure might influence on the development of ADHD. But these results suggest that the lead exposure affect the school performance in ADHD patients. 
32nd Annual Meeting of the Neurobehavioral Teratology Society/48th Annual Meeting of the Teratology Society/21st Annual Meeting of the Organization of Teratology Information Specialists 
Monterey, CA 
June 28-July 2, 2008