Health & Environmental Research Online (HERO)


Print Feedback Export to File
501966 
Journal Article 
From the bench to the bedside: emerging new treatments in multiple myeloma 
Mitsiades, CS; Hayden, PJ; Anderson, KC; Richardson, PG 
2007 
20 
4 
797-816 
English 
18070720 
WOS:000252142800015 
Within the last decade, several novel classes of anti-myeloma therapeutics have become available. The clinical successes achieved by thalidomide, lenalidomide, and the proteasome inhibitor bortezomib, and in particular the ability of these agents to lead to major clinical responses in patients resistant to conventional or high-dose chemotherapy, have highlighted the importance of expanding further the spectrum of classes of agents utilized for the treatment of myeloma. Herein, we review the current status for the development of novel anti-myeloma agents, with emphasis on classes of therapeutics which have already translated into clinical trials or those in advanced stages of preclinical development. These include second-generation proteasome inhibitors (NPI-0052 and PR-171), heat shock protein 90 (hsp90) inhibitors, 2-methoxyestradiol, histone deacetylase (HDAC) inhibitors (e.g. SAHA and LBH589), fibroblast growth factor receptor 3 (FGF-R3) inhibitors, insulin-like growth factor 1 receptor (IGF-1R) inhibitors, mTOR inhibitors, monoclonal antibodies, and agents specifically targeting the tumor microenvironment, such as defibrotide. 
myeloma; targeted therapy; immunomodulatory; thalidomide; lenalidomide; bortezomib; hsp90 inhibitor; nf-kappa-b; bone-marrow microenvironment; overcomes drug-resistance; histone deacetylase inhibition; ubiquitin-proteasome pathway; acid; combination therapy; phase-ii; antitumor-activity; arsenic trioxide; tyrosine kinase