Inhibition of human erythrocyte (Na+-K+)ATPase by organic hydroperoxides and protection by ascorbic acid and butylated hydroxytoluene | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

5028703

Reference Type

Journal Article

Title

Inhibition of human erythrocyte (Na+-K+)ATPase by organic hydroperoxides and protection by ascorbic acid and butylated hydroxytoluene

Author(s)

Yesilkaya, A; Yegin, A

Year

1998

Is Peer Reviewed?

Yes

Journal

General Pharmacology
ISSN: 0306-3623
EISSN: 1879-0011

Volume

Issue

Page Numbers

495-498

Language

English

DOI

10.1016/S0306-3623(97)00285-1

Web of Science Id

WOS:000072281900009

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032053973&doi=10.1016%2fS0306-3623%2897%2900285-1&partnerID=40&md5=2ea2ba2f263fe7640cba4ec237bf1b4f
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Abstract

1. The in vitro effects of cumene hydroperoxide and t-butyl hydroperoxide on intact human erythrocyte membrane (Na+-K+)ATPase activities have been studied. 2. (Na+-K+)ATPase activities on erythrocyte membranes decreased in agreement with the results of chemiluminescence experiments. 3. Our results demonstrated that the organic hydroperoxides inhibit the activity of (Na+-K+)ATPase enzyme and that the antioxidants used prevent this inhibition.

Keywords

erythrocyte membrane; organic hydroperoxides; (Na+-K+)ATPase; ascorbic acid; butylated hydroxytoluene