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503772 
Journal Article 
Royal Jelly Reduces the Serum Glucose Levels in Healthy Subjects 
Munstedt, K; Bargello, M; Hauenschild, A 
2009 
Yes 
Journal of Medicinal Food
ISSN: 1096-620X
EISSN: 1557-7600 
12 
5 
1170-1172 
English 
19857086 
WOS:000271145900034 
Earlier biological investigations have shown that royal jelly has insulin-like activity. However, there have so far been no clinical trials to support these findings. The objective of the present study was to study the effect of royal jelly ingestion on the glucose metabolism of healthy humans. Twenty volunteers underwent the standardized oral glucose tolerance test (OGTT) and afterwards a second OGTT after ingestion of 20 g of royal jelly. Serum glucose levels after 2 hours and the area under the curve for glucose were significantly lower (P = .041) after royal jelly administration. Substances originating from the pharyngeal glands of the honey bee with insulin-like activity are likely to have caused this effect and may thus be, at least partially, responsible for the lowering impact of honey on blood glucose levels. The identification of the substances that seem to act even after passage through the human stomach could lead to the development of new concepts in diabetology. 
C-peptide; fructose; glucose; insulin; royal jelly; insulin-resistance; honey; tolerance; fructose; sucrose; foods; rats