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5041713 
Journal Article 
Bone neo-formation and mineral degradation of 4Bone.(®) Part II: histological and histomorphometric analysis in critical size defects in rabbits 
Calvo-Guirado, JL; Maté-Sánchez, JE; Delgado-Ruiz, RA; Romanos, GE; De Aza-Moya, P; Velázquez, P 
2015 
Yes 
Clinical Oral Implants Research
ISSN: 0905-7161
EISSN: 1600-0501 
26 
12 
1402-1406 
English 
25163802 
WOS:000364314100008 
has retraction 4820126 Bone neo-formation and mineral degradation of 4Bone. (R) Part II: histological and histomorphometric analysis in critical size defects in rabbits (Retraction of Vol 26, Pg 1402, 2015)
OBJECTIVE: To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic.

MATERIALS AND METHOD: In this study, porous HA/βTCP (4Bone(®) ) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic's components HA/βTCP was 60/40 (in wt%).

RESULTS: The 4Bone(®) showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52).

CONCLUSIONS: 4Bone(®) is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.