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504381 
Journal Article 
Newly developed signal-averaged vector-projected 187-channel electrocardiogram can evaluate the spatial distribution of repolarization heterogeneity 
Nakai, K; Miyake, F; Kasanuki, H; Shoda, M; Futagawa, K; Takahashi, A; Matsuyama, Y; Nirei, T; Tsuboi, J; Okabayashi, H; Itoh, M; Kawata, H 
2008 
Yes 
International Heart Journal
ISSN: 1349-2365 
49 
2 
153-164 
English 
The purpose of this study was to verify the spatial distribution of myocardial repolarization heterogeneity using a newly developed 187-channel signal-averaged vector-projected ECG (187-ch SAVP-ECG). We constructed corrected recovery time (RTc) and Tpeak-end (corrected Tp-e) dispersion maps using a 187-ch SAVP-ECG based on vector-projection theory using a Mason-Likar lead system. We compared the spatial distribution and quantitative values of dispersion maps by 187-ch SAVP-ECG with those by 64-ch magnetocardiography (MCG) in 27 normal controls (control) and 16 patients (12 myocardial infarction (MI), and 4 dilated cardiomyopathy (DCM)). The wave pattern of the 187-ch SAVP-ECG in the representative cases was similar to those in 64-ch MCG. Spatial distribution increased RTc and corrected Tp-e dispersion maps defined by 187-ch SAVP-ECG were in agreement with those by 64-ch MCG. The value of RTc dispersion in MI was higher than that in control (41 +/- 21 ms in MI versus 30 +/- 12 ms in control, P < 0.05). The value of corrected Tp-e dispersion in DCM was higher than that in control (58 +/- 12 ms in DCM versus 30 +/- 13 ms in control, P < 0.001). There was a good correlation between RTc and corrected Tp-e dispersion values determined by 187-ch SAVP-ECG and 64-ch MCG modalities (y = 0.46x + 18, r = 0.62, P = 0.02 for RTc dispersion; y = 0.52x + 15, r = 0.63, P = 0.01 for corrected Tp-e dispersion). RTc and corrected Tp-e dispersion maps by 187-ch SAVP-ECG based on vector-projection theory can evaluate the spatial distribution of myocardial repolarization heterogeneity. 
signal-averaged ECG; body surface mapping; vector projection; recovery; time dispersion; repolarization heterogeneity; torsade-de-pointes; qt interval; ventricular repolarization; long-qt; transmural dispersion; e14 guideline; prolongation; activation; drugs; location