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HERO ID
5046692
Reference Type
Journal Article
Subtype
Review
Title
Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration
Author(s)
Cloyd, RA; Koren, SA; Abisambra, JF
Year
2018
Is Peer Reviewed?
Yes
Journal
Frontiers in Aging Neuroscience
ISSN:
1663-4365
Volume
10
Page Numbers
403
Language
English
PMID
30618710
DOI
10.3389/fnagi.2018.00403
Web of Science Id
WOS:000453325700002
Abstract
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and the brief but decorated clinical usage of chelated manganese compound mangafodipir in humans.
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