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HERO ID
505357
Reference Type
Journal Article
Title
Metastasis: from dissemination to organ-specific colonization
Author(s)
Nguyen, DX; Bos, PD; Massague, J
Year
2009
Is Peer Reviewed?
1
Journal
Nature Reviews. Cancer
ISSN:
1474-175X
EISSN:
1474-1768
Volume
9
Issue
4
Page Numbers
274-U265
Language
English
DOI
10.1038/nrc2622
Abstract
Metastasis to distant organs is an ominous feature of most malignant tumours but the natural history of this process varies in different cancers. The cellular origin, intrinsic properties of the tumour, tissue affinities and circulation patterns determine not only the sites of tumour spread, but also the temporal course and severity of metastasis to vital organs. Striking disparities in the natural progression of different cancers raise important questions about the evolution of metastatic traits, the genetic determinants of these properties and the mechanisms that lead to the selection of metastatic cells.
Keywords
breast-cancer metastasis; cytokeratin-positive cells; epithelial-mesenchymal transition; bone-marrow; lung metastasis; tumor; dormancy; tgf-beta; prostate-cancer; stem-cells; neoplastic; transformation
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