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5063059 
Journal Article 
A step-ladder manganese(III) metallacrown hosting mefenamic acid and a manganese(II)-mefanamato complex: synthesis, characterization and cytotoxic activity 
Tarushi, A; Geromichalos, GD; Lafazanis, K; Raptopoulou, CP; Psycharis, V; Lalioti, N; Pantazaki, AA; Kessissoglou, DP; Tangoulis, V; Psomas, G 
2018 
1 
New Journal of Chemistry
ISSN: 1144-0546
EISSN: 1369-9261 
42 
9 
6955-6967 
WOS:000431819200051 
The interaction of Mn(II) with the non-steroidal anti-inflammatory drug mefenamic acid (Hmef) in the presence or absence of salicylaldoxime (H(2)sao) leads to the formation of the hexanuclear Mn(III) cluster [Mn-6(O)(2)(mef)(2)(sao)(6)(CH3OH)(4)] 1, characterized as stepladder inverse-9-metallacrown-3 accommodating mefenamato ligands, or the mononuclear Mn(II) complex [Mn(mef)(2)(CH3OH)(4)], 2, respectively. Both complexes were characterized by physicochemical and spectroscopic techniques and the structure of complex 1 was characterized by X-ray crystallography. The overall magnetic behavior of compound 1 is antiferromagnetic with a high-spin well-isolated ground state S = 4. The in vitro cytotoxic effects of the complexes were evaluated against three cancer cell lines (HeLa, MCF-7 and A549 cells) as well as their combinatory activity with the well-known chemotherapeutic drugs cisplatin and 5-fluorouracil. Furthermore, in silico predictive tools have been employed to study the properties and acute rat toxicity and cell line cytotoxicity of the most active complex.