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5063761 
Journal Article 
Green-Light-Induced PhotoCORM: Lysozyme Binding Affinity towards Mn-I and Re-I Carbonyl Complexes and Biological Activity Evaluation 
Mansour, AM 
2018 
Yes 
European Journal of Inorganic Chemistry
ISSN: 1434-1948
EISSN: 1099-0682 
2018 
44 
4805-4811 
English 
WOS:000451698400006 
Reaction of N-(2-pyridylmethylene)benzene-1,4-diamine (L) with [MBr(CO)(5)] (M = Mn-I and Re-I) affords complexes of the type [MBr(CO)(3)L] [M = Mn-I (1) and Re-I (2)]. Complex 1 releases CO upon illumination with light in the range of 525-468 nm. No photo induced CO release is detected from 2. Reactive azide complex 3, obtained by bromide's ligand exchange, reacts with the electron-poor alkyne dimethyl acetylene dicarboxylate giving triazolato complex 4 ([Mn(triazolate(COOMe,COOMe))(CO)(3)L]) via the free catalyst [3+2] cycloaddition coupling. Complex 1 exhibits interesting antifungal activity (MIC = 30 nM) against Candida albicans and Cryptococcus neoformans as well as cytotoxic activity of 12.56 mu g/mL against noncancerous human embryonic kidney cells. Reactivity of the complexes towards hen egg white lysozyme is studied by electrospray ionization mass spectrometry. 
Biological; Carbon monoxide; Lysozyme binding affinity; Photoactivatable; TDDFT