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HERO ID
506647
Reference Type
Journal Article
Title
Strategies for use of IL-10 or its antagonists in human disease
Author(s)
O'Garra, A; Barrat, FJ; Castro, AG; Vicari, A; Hawrylowicz, C
Year
2008
Is Peer Reviewed?
Yes
Journal
Immunological reviews
ISSN:
0105-2896
EISSN:
1600-065X
Volume
223
Page Numbers
114-131
Language
English
Abstract
Interleukin-10 (IL-10) is a cytokine with broad anti-inflammatory properties by its suppression of both macrophage and dendritic cell function, including antigen-presenting cell function and the production of proinflammatory cytokines. This can result subsequently in the feedback regulation of both T-helper 1 (Th1)-type and Th2-type responses. This review discusses the potential use of IL-10 or agents that induce IL-10 as potential anti-inflammatory therapies in inflammatory diseases. Although IL-10-deficient mice develop colitis in the presence of normal gut flora and clear certain intracellular pathogens more efficiently, this is often accompanied by immunopathology, which can be lethal to the host. This reinforces the anti-inflammatory properties of IL-10, although it should be noted that as discussed below, IL-10 can also promote B-cell and other immune responses under particular settings. A penalty of its role to limit the immune and inflammatory responses to pathogens and prevent damage to the host is that high or dysregulated levels of IL-10 may result in chronic infection. Thus, antagonists of IL-10 show great potential as adjuvants in preventative or therapeutic vaccines against chronic infection or cancer. This article reviews basic published studies on IL-10, which may lead to potential uses of IL-10 or its antagonists in human disease.
Keywords
IL-10; anti-inflammatory; cytokines; regulatory t-cells; experimental autoimmune encephalomyelitis; experimental allergic encephalomyelitis; plasmacytoid dendritic cells; tumor-associated macrophages; growth-factor-beta; inhibits cytokine; production; serum interleukin-10 levels; induced immune dysfunction; colony-stimulating factor
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