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5073822 
Journal Article 
Phosphine-Free NNN-Manganese Complex Catalyzed alpha-Alkylation of Ketones with Primary Alcohols and Friedlander Quinoline Synthesis 
Barman, MK; Jana, A; Maji, B 
2018 
1 
Advanced Synthesis & Catalysis
ISSN: 1615-4150
EISSN: 1615-4169 
360 
17 
3233-3238 
WOS:000443377800005 
Herein, we report a very simple and inexpensive catalytic system based on Earth's abundant transition metal manganese and on a bench-stable phosphine-free NNN-pincer ligand for an atom-efficient alpha-alkylations of ketones with primary alcohols via hydrogen-autotransfer C-C bond formation protocol. The precatalyst could be generated insitu and could be activated by using catalytic amount of base under milder conditions. A range of ketones were efficiently diversified with a broad range of primary alcohols in good to excellent isolated yields. Remarkably, this catalyst could also be employed for the synthesis of quinoline derivatives using 2-aminobenzyl alcohol as an alkylating agent. The later reaction is highly benign producing only hydrogen and water as byproducts. 
Alkylation; Manganese catalysts; Hydrogen-autotransfer; Friedlander reaction; NNN-pincer