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508890 
Journal Article 
Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes 
Park, MJ; Gwak, KS; Yang, I; Kim, KW; Jeung, EB; Chang, JW; Choi, IG 
2009 
Yes 
Fitoterapia
ISSN: 0367-326X 
80 
5 
290-296 
English 
19345255 
The antifungal effects of citral, eugenol, nerolidol and a-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T mentagrophytes, and the antifungal activity of alpha-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 02, 0.4 and 1 mg/ml of eugenol, nerolidol and alpha-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. (C) 2009 Elsevier B.V. All rights reserved. 
Citral; Nerolidol; Eugenol; alpha-Terpineol; Trichophyton; mentagrophytes; Electron microscopy; essential oils; antifungal activity; amorolfine; constituents