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50921 
Journal Article 
Developmental toxicity of cyclohexanediamine-tetraacetic acid (CDTA) in mice 
Sanchez, DJ; Colomina, MT; Domingo, JL; Llobet, JM; Corbella, J 
1994 
Research Communications in Molecular Pathology and Pharmacology
ISSN: 1078-0297 
BIOSIS/94/15936 
83 
329-340 
English 
BIOSIS COPYRIGHT: BIOL ABS. Cyclohexanediaminetetraacetic acid (CDTA), an effective antagonist for the treatment of zinc, lead, and manganese poisoning was evaluated for maternal and developmental toxicity in pregnant Swiss mice. CDTA was given intraperitoneally on gestation days 6-15 at doses of 0, 270, 540, and 1080 mg/kg/day. On gestational day 18, the fetuses were examined for external, visceral, and skeletal malformations and variations. Treatment with CDTA at 1080 mg/kg/day resulted in a high level of maternal deaths, as well as less severe clinical signs (significant reduction in weight gain and food consumption). Increased resorptions, fetal deaths, and decreased number of live fetuses per litter were observed at 1080 mg/kg/day. Mean fetal body weights were also significantly decreased in this group. At 1080 mg/kg/day, CDTA caused external malformations, while the development of skeletal tissues was less affected. The no observable adverse effect level (NOAEL) for maternal and developmenta