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Citation
Tags
HERO ID
509733
Reference Type
Journal Article
Subtype
Review
Title
Biochemistry of protein tyrosine nitration in cardiovascular pathology
Author(s)
Peluffo, G; Radi, R
Year
2007
Is Peer Reviewed?
Yes
Journal
Cardiovascular Research
ISSN:
0008-6363
EISSN:
1755-3245
Volume
75
Issue
2
Page Numbers
291-302
Language
English
PMID
17544386
DOI
10.1016/j.cardiores.2007.04.024
Web of Science Id
WOS:000248296300010
Abstract
Several pathologies of the cardiovascular system are associated with an augmented production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the antioxidant detoxification pathways that lead to nitroxidative stress. One important consequence of these reactive intermediates at the biochemical level is the nitration of protein tyrosines, which is performed through either of two of the relevant nitration pathways that operate in vivo, namely peroxynitrite and heme peroxidase-dependent nitration. Proteins nitrated at tyrosine residues have been detected in several compartments of the cardiovascular system. In this review a selection of nitrated proteins in plasma (fibrinogen, plasmin, Apo-1), vessel wall (Apo-B, cyclooxygenase, prostaglandin synthase, Mn-superoxide dismutase) and myocardium (myofibrillar creatine kinase, a-actinin, sarcoplasmic reticulum Ca2+ ATPase) are analyzed in the context of cardiovascular disease. Nitration of tyrosine can affect protein function, which could directly link nitroxidative stress to the molecular alterations found in disease. While some proteins are inactivated by nitration (e.g. Mn-SOD) others undergo a gain-of-function (e.g. fibrinogen) that can have an ample impact on the pathophysiology of the cardiovascular system. Nitrotyrosine is also emerging as a novel independent marker of cardiovascular disease. Pharmacological strategies directed towards inhibiting protein nitration will assist to shed light on the relevance of this post-translational modification to human cardiovascular pathology. (c) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
Keywords
free radicals; nitric oxide; nitration; nitroxidative stress; nitrotyrosine; peroxynitrite; nitric-oxide synthase; sarcoplasmic-reticulum ca2+-atpase; manganese-superoxide-dismutase; apolipoprotein-a-i; prostaglandin; endoperoxide synthase; human atherosclerotic intima; experimental; heart-failure; high-density-lipoprotein; peroxynitrite formation; prostacyclin synthase
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