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5098681 
Journal Article 
Influence of tablet excipients on hydrolysis of sodium acetylsalicylate by increased temperature and low humidity 
Mielck, JB; Rabach, H 
1984 
Yes 
Acta Pharmaceutica
ISSN: 1330-0075 
30 
1 
IPA COPYRIGHT: ASHP Avicel (microcrystalline cellulose), Emcompress (calcium phosphate dibasic dihydrate) and Sta-Rx-1500 (starch) were used as excipients in sodium acetylsalicylate (I) tablets, and their effects on I hydrolysis at elevated temperatures and low humidity were studied. Initial rates and rate constants calculated from the contracting sphere and nucleation models showed that hydrolysis was fastest with starch, followed by calcium phosphate dibasic and then microcrystalline cellulose. The possible effects of porosity and of water content of the excipients were considered.