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5098704 
Journal Article 
Compatibility study between atenolol and tablet excipients using differential scanning calorimetry 
Botha, SA; Lotter, AP 
1990 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
16 
1 
English 
IPA COPYRIGHT: ASHP In order to improve the formulation of atenolol, the physicochemical compatibility between the drug and various excipients commonly used in tablet manufacturing was studied with differential scanning calorimetry. Atenolol is compatible with starch (STA-Rx), sodium starch glycolate (Primojel), cellulose microcrystalline (Avicel PH), croscarmellose sodium (Ac-Di-Sol), crospovidone (cross-linked PVP; cross-linked polyvinylpyrrolidone), magnesium stearate, calcium sulfate dihydrate, calcium phosphate dibasic (dicalcium phosphate), and icing sugar. Interactions of atenolol with povidone, lactose, and the lubricant stearic acid were found, although it cannot be conclusively stated that interaction incompatibilities will occur during storage at room temperature.