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5098728 
Journal Article 
Disintegrating agents in hard gelatin capsules. Part 1. Mechanism of action 
Botzolakis, JE; Augsburger, LL 
1988 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
14 
1 
English 
IPA COPYRIGHT: ASHP AcDiSol (croscarmellose sodium; I), Primojel (sodium starch glycolate), Polyplasdone XL-10 (crospovidone) and corn starch were evaluated as disintegrants in lactose and calcium phosphate dibasic based hard gelatin capsule formulations. Hydrochlorothiazide, used as a model drug with low water solubility, was released fastest in formulations containing I. A minimum disintegrant concentration was necessary to produce primary particles upon disintegration and significantly affect dissolution. Swelling characteristics of the disintegrant were most important for improved dissolution and overall disintegrant effectiveness.