Dicalcium phosphate dihydrate for direct compression: characterization and intermanufacturer variability | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5098770

Reference Type

Journal Article

Title

Dicalcium phosphate dihydrate for direct compression: characterization and intermanufacturer variability

Author(s)

Landin, M; Martinez-Pacheco, R; Gomez-Amoza, JL; Souto, C; Rowe, RC; Et al

Year

1994

Is Peer Reviewed?

Yes

Journal

International Journal of Pharmaceutics
ISSN: 0378-5173
EISSN: 1873-3476

Volume

109

Issue

Aug 22 1994

Language

English

Abstract

IPA COPYRIGHT: ASHP The structure, dehydration behavior, and particle characteristics of calcium phosphate dibasic dihydrate (dicalcium phosphate dihydrate; DCPD) of two brands of unmilled calcium phosphate dibasic dihydrate currently available for direct compression (Emcompress; DiTab) were compared with two typical powders (Calipharm; Kyowa). Results indicated that the two unmilled brands were very similar in structure, particle characteristics, and dehydration behavior. The processing undergone by unmilled DCPD for direct compression does not cause major changes in crystal structure, mechanical, and surface properties with respect to typical powders. However, considerable differences in dehydration behavior between the unmilled DCPDs and the typical milled product were noted, probably due to the larger mean particle size and different particle structure of the direct compression preparations.