Dicalcium phosphate dihydrate and anhydrous dicalcium phosphate for direct compression: comparative study | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5098787

Reference Type

Journal Article

Title

Dicalcium phosphate dihydrate and anhydrous dicalcium phosphate for direct compression: comparative study

Author(s)

Doldan, C; Souto, C; Concheiro, A; Martinez-Pacheco, R; Gomez-Amoza, JL

Year

1995

Is Peer Reviewed?

Yes

Journal

International Journal of Pharmaceutics
ISSN: 0378-5173
EISSN: 1873-3476

Volume

124

Issue

Sep 19 1995

Language

English

Abstract

IPA COPYRIGHT: ASHP Calcium phosphate dibasic dihydrate (dicalcium phosphate dihydrate; Emcompress) and calcium phosphate dibasic (dicalcium phosphate anhydrous) for direct compression were compared with respect to particle size distribution, flow properties, microporous structure, and compression properties. Particle size distribution and flow properties were similar for the 2 products, while microporous structure and compression properties differed markedly. Intraparticular porosity and mean yield pressure of the anhydrous product were greater than for the dihydrate. Compacts of the anhydrous product disintegrated much more rapidly in distilled water than did those of the dihydrate. This was attributed to the greater porosity of the former compacts.