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5098807 
Journal Article 
Degradation of bisoprolol fumarate in tablets formulated with dicalcium phosphate 
Dulin, WA 
1995 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
21 
4 
English 
IPA COPYRIGHT: ASHP The stability of bisoprolol fumarate tablet dosage forms with granular calcium phosphate dibasic (dicalcium phosphate anhydrous) is reported. Instability of the drug with the granular material was due to an acidic environment created by this material in the presence of moisture. Bisoprolol is less stable at low pH compared to the neutral pH created with milled calcium phosphate dibasic.