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5121024 
Journal Article 
Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system 
Huang, X; He, J; Niu, X; Menzel, KD; Dahse, HM; Grabley, S; Fiedler, HP; Sattler, I; Hertweck, C 
2008 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
47 
21 
3995-3998 
English 
18412200 
WOS:000255994700029 
A natural benzopyren: The title compound 1 was discovered by chemical metabolite profiling of a large-scale fermentation of Streptomyces lavendulae. Biological evaluation of the peri-fused pentacyclic compound revealed antitumor activity against several cell lines. The co-occurrence of an angucyclic polyketide with an identical ring-substitution pattern suggests that 1 is biosynthesized from an angular decaketide and a C3 building block. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. 
Antitumor agents; Benzopyrenes; Natural products; Polyketides; Structure elucidation