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5124512 
Journal Article 
Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia 
Kampalath, BN; Liau, MC; Burzynski, B; Burzynski, SR 
1987 
Yes 
Drugs Under Experimental and Clinical Research
ISSN: 0378-6501 
13 Suppl 1 
51-55 
English 
3569016 
The effect of Antineoplaston A10 (AA10), an amino acid derivative isolated from human urine, has been studied on pulmonary adenoma formation resulting from intragastric administration of benzo(a)pyrene(BP) to A/HeJ mice. Two doses of BP, 3 mg each, administered two weeks apart, induced an average of 6.86 tumours within 157 days in the control animals (Tumorigenic Index 437). One per cent of AA10 (w/w) given in mouse food for one week prior to, and then continued after the administration of BP, produced a 70% reduction in the total number of tumours in the test groups.