The effect of sodium phenobarbital and 3,4-benzpyrene on the glucuronidation of 1-naphthol in rat small intestinal loops in vivo | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5126739

Reference Type

Journal Article

Title

The effect of sodium phenobarbital and 3,4-benzpyrene on the glucuronidation of 1-naphthol in rat small intestinal loops in vivo

Author(s)

Turner, JC; Shanks, V; Kelly, WJ; Green, RS

Year

1977

Is Peer Reviewed?

Yes

Journal

General Pharmacology
ISSN: 0306-3623
EISSN: 1879-0011

Publisher

Elsevier

Volume

Issue

Page Numbers

51-53

Language

English

PMID

590723

DOI

10.1016/0306-3623(77)90065-9

Web of Science Id

WOS:A1977DD48100010

URL

https://linkinghub.elsevier.com/retrieve/pii/0306362377900659
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Abstract

1. 1. After 0.1 mM 1-naphthol was injected into intestinal loops, 70-90% of the 1-naphthol in the intestinal venous blood was present as 1-naphthol glucuronide. For 1.0 and 2.0 mM injections the proportion of 1-naphthol present as 1-naphthol glucuronide was 25-50%. 2. 2. The proportion of 1-naphthol glucuronide in the intestinal venous blood was increased by oral dosing of either sodium phenobarbital or 3,4-benzpyrene but these compounds did not alter the rate of appearance of 1-naphthol, free or conjugated. Â© 1977.