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5128387 
Technical Report 
Induction of liver microsomal cytochrome P-450 and associated monooxygenases by octachlorostyrene in the rat 
Holme, JA; Dybing, E 
1981 
MUNKSGAARD INT PUBL LTD 
COPENHAGEN 
1 
47-47 
WOS:A1981MA01600037 
PESTAB. Rats were used in studies to determine the effects of single ip doses of octachlorostyrene (OCS) and hexachlorobenzene (HCB) on liver microsome parameters. Results are compared with those from the model inducers phenobarbitol and 3-methylcholanthrene. Both OCS and HCB increased microsomal protein and cytochrome P-450 contents, and activities of cytochrome P-450 reductase, ethylmorphine N-demethylase, paranitroanisole O-demethylase and acetanilide 4-hydroxylase. Cytochrome b5 and arylhydrocarbon [benzo(a)pyrene] hydroxylase were not affected. It is concluded that under these experimental conditions, OCS and HCB are primarily inducers of the phenobarbitol class. [Presented at the 23rd Scandinavian Pharmacol. Soc. meet.] 
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