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512850 
Journal Article 
Molecular regulation of HDL metabolism and function: implications for novel therapies 
Rader, DJ 
2006 
Yes 
Journal of Clinical Investigation
ISSN: 0021-9738
EISSN: 1558-8238 
116 
12 
3090-3100 
English 
HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our under standing of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics. 
high-density-lipoprotein; apolipoprotein-a-i; ester transfer protein; reverse cholesterol transport; receptor class-b; phospholipid transfer; protein; coronary-artery-disease; liver-x-receptor; e-deficient mice; abcg1(-/-) bone-marrow