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Citation
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HERO ID
512850
Reference Type
Journal Article
Title
Molecular regulation of HDL metabolism and function: implications for novel therapies
Author(s)
Rader, DJ
Year
2006
Is Peer Reviewed?
Yes
Journal
Journal of Clinical Investigation
ISSN:
0021-9738
EISSN:
1558-8238
Volume
116
Issue
12
Page Numbers
3090-3100
Language
English
DOI
10.1172/jci30163
Abstract
HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our under standing of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.
Keywords
high-density-lipoprotein; apolipoprotein-a-i; ester transfer protein; reverse cholesterol transport; receptor class-b; phospholipid transfer; protein; coronary-artery-disease; liver-x-receptor; e-deficient mice; abcg1(-/-) bone-marrow
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