Benz(a)anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin modulate mitogen-stimulated lymphocyte proliferation | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5128590

Reference Type

Technical Report

Title

Benz(a)anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin modulate mitogen-stimulated lymphocyte proliferation

Author(s)

Lozovatskii, AL; Ostashevskii, VA; Perminova, OM; Kozlov, VA; Tsyrlov, IB

Year

1990

Is Peer Reviewed?

Yes

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888
EISSN: 1573-8221

Publisher

Kluwer Academic Publishers-Plenum Publishers

Volume

109

Issue

Page Numbers

569-571

Language

Russian

DOI

10.1007/BF00841438

Web of Science Id

WOS:A1990ET45200022

Abstract

BIOSIS COPYRIGHT: BIOL ABS. The influence of benzo(a) anthracene (BA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on functional properties of peripheral blood mononuclear cells (PBC) has been investigated. Incubation of mitogen-stimulated cells in the presence of xenobiotics induced high activity of benzo(a) pyrene-hydroxylase (BH) and suppressed lymphocyte blast transformation. Preincubation of unstimulated PBC with BA and TCDD caused significant increase of BH activity. The results show modulated effect of xenobiotics on functional properties of PBC.

Keywords

LYMPHOCYTES; PROLIFERATION; XENOBIOTICS; BENZPYRENE HYDROXYLASE