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5138156 
Journal Article 
Multiple Keratoses and Squamous Cell Carcinoma from Cutting Oil 
Tsuji, T; Otake, N; Kobayashi, T; Miwa, N 
1992 
Yes 
Journal of the American Academy of Dermatology
ISSN: 0190-9622
EISSN: 1097-6787 
27 
5 
767-768 
English 
A case study of a 58 year old Japanese metal cutting worker who developed multiple keratoses and squamous cell carcinoma as a result of working with cutting oil was presented. He had been exposed to cutting oil 9 hours/day, 6 days/week for about 15 years. He had scaly or keratotic plaques, papules, and nodules with or without pigmentation on the extensor and flexor aspects of his forearms and backs of his hands. There was a 3 centimeter crateriform nodule on the flexor surface of his forearm. Examination of the nodule revealed an invading tumor with masses of epidermal cells invading the dermis, and atypical squamous cell hyperplasia. Analysis of unused cutting oil showed that it contained the polycyclic aromatic hydrocarbon 3,4-benzopyrene (50328) a known carcinogen that is also found in other machine oils distilled from petroleum.