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5142900 
Journal Article 
Effect of temperature on the P4501A response in winter- and summer-acclimated Arctic char (Salvelinus alpinus) after oral benzo(a)pyrene exposure 
Jorgensen, EH; Wolkers, J 
1999 
Yes 
Canadian Journal of Fisheries and Aquatic Sciences
ISSN: 0706-652X
EISSN: 1205-7533 
National Research Council of Canada 
OTTAWA 
56 
8 
1370-1375 
English 
WOS:000082326800005 
BIOSIS COPYRIGHT: BIOL ABS. In this study, the time-dependent P450 response to oral benzo(a)pyrene exposure at 1 and 10?C was investigated in winter- and summer-acclimated Arctic char (Salvelinus alpinus). In both seasons, a strong induction of CYP1A activities and protein levels (measured only in the winter experiment) were seen at both 1 and 10?C. At 1?C, the responses were delayed and more long-lasting than at 10?C. No within-season difference between 1 and 10?C in the magnitude of the induction response was found, but itoring polycyclic aromatic hydrocarbon contamination in high-latitude environments. More studies are needed, however, to reveal seasonal differences in the biomarker response to pollutants.