Health & Environmental Research Online (HERO)


Print Feedback Export to File
5148447 
Journal Article 
Some Effects of Carcinogenic Agents on Mice Subject to Spontaneous Leukoses 
Morton, JJ; Mider, GB 
1941 
Yes 
Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445 
1 
2 
The effects of carcinogenic agents on mice subject to spontaneous leukoses were investigated in experimental studies. The appearance of leukosis in dilute brown mice was hastened by painting them with a 0.5 percent or 0.25 percent solution of methylcholanthrene (56495) in benzene (71432), 0.25 percent methylcholanthrene in acetone (67641), or 0.5 percent 3,4-benzpyrene (50328) in benzene. Painting with benzene alone did not have an effect of the same magnitude. Incidence of leukosis in line 212 of the dilute brown strain is greater after painting with methylcholanthrene than after painting with benzpyrene. Leukosis was found in old Buffalo, new Buffalo, and C3H mice after painting with 0.5 percent methylcholanthrene in benzene but not in the C57 black or C albino strains. All these mice are known to develop spontaneous leukosis although the incidence is not established.