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5168356 
Journal Article 
Synthesis of Water-Soluble Chitosan-g-PEO and Its Application for Preparation of Superparamagnetic Iron Oxide Nanoparticles in Aqueous Media 
Choi, JH; Lee, S; Kang, HJ; Lee, JY; Kim, J; Yoo, HO; Stratton, TR; Applegate, BM; Youngblood, JP; Kim, HJ; Ryu, KN 
2010 
1 
Macromolecular Research
ISSN: 1598-5032 
POLYMER SOC KOREA 
SEOUL 
18 
5 
504-511 
English 
WOS:000282470200014 
A simple and useful method to synthesize water-soluble chitosan is proposed. Water-soluble chitosan-g-poly(ethylene oxide) could be synthesized readily by modification of authentic chitosan with a 150,000 g/mol molecular weight using omega-anhydride-functionalized poly(ethylene oxide)s (PEOs) with or without small molecular anhydride compounds, such as phthalic anhydride or acetic anhydride through a 'grafting onto' method. The PEO-grafting method in the presence of acetic anhydride leading to partial acetylation appears to be more effective in synthesizing relatively high water-soluble chitosan. The bactericidal properties of PEO-modified chitosan and small molecular anhydride over a moderate concentration range (over 500 mu g/mL) suggest that they might be used in the biomedical field. The PEO-grafted chitosans were used successfully as polymeric stabilizers to prepare nano-sized iron oxide particles as a magnetic resonance imaging contrast agent for tumor cells. The size of the iron oxide nanoparticles stabilized by modified chitosans was controlled in the range of 5 to 30 nm with superparamagnetic properties in aqueous media. All the materials were characterized by H-1 NMR, UV/Visible spectroscopy, TEM, magnetization, and XRD pattern analyses. 
Polymer Science; water-soluble chitosan, omega-anhydride-functionalized PEO,; bactericidal, superparamagnetic iron oxide nanoparticles, magnetization; magnetic nanoparticles, polysaccharide