Journal Article
Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome - A multicenter study
Sacher, F; Probst, V; Iesaka, Y; Jacon, P; Laborderie, J; Mizon-Gerard, F; Mabo, P; Reuter, S; Lamaison, D; Takahashi, Y; O'Neill, MD; Garrigue, S; Pierre, B; Jais, P; Pasquie, JL; Hocini, M; Salvador-Mazenq, M; Nogami, A; Amiel, A; Defaye, P; Bordachar, P; Boveda, S; Maury, P; Klug, D; Babuty, D; Haissaguerre, M; Mansourati, J; Clementy, J; Le Marec, H
Circulation
ISSN: 0009-7322
EISSN: 1524-4539
Background - Brugada syndrome is an arrhythmogenic disease characterized by an increased risk of sudden cardiac death (SCD) by ventricular fibrillation. At present, an implantable cardioverter-defibrillator (ICD) is the recommended therapy in high-risk patients. This multicenter study reports the outcome of a large series of patients implanted with an ICD for Brugada syndrome. Methods and Results - All patients (n = 220, 46 +/- 12 years, 183 male) with a type 1 Brugada ECG pattern implanted with an ICD in 14 centers between 1993 and 2005 were investigated. ICD indication was based on resuscitated SCD (18 patients, 8%), syncope (88 patients, 40%), or positive electrophysiological study in asymptomatic patients (99 patients, 45%). The remaining 15 patients received an ICD because of a family history of SCD or nonsustained ventricular arrhythmia. During a mean follow-up of 38 +/- 27 months, no patient died and 18 patients (8%) had appropriate device therapy (10 +/- 15 shocks/patient, 26 +/- 33 months after implantation). The complication rate was 28%, including inappropriate shocks, which occurred in 45 patients (20%, 4 +/- 3 shocks/patient, 21 +/- 20 months after implantation). The reasons for inappropriate therapy were lead failure (19 patients), T-wave oversensing (10 patients), sinus tachycardia (10 patients), and supraventricular tachycardia (9 patients). Among implantation parameters, high defibrillation threshold, high pacing threshold, and low R-wave amplitude occurred, respectively, in 12%, 27%, and 15% of cases. Conclusion - In this large Brugada syndrome population, a low incidence of arrhythmic events was found, with an annual event rate of 2.6% during a follow-up of > 3 years, in addition to a significant risk of device-related complications (8.9%/year). Inappropriate shocks were 2.5 times more frequent than appropriate ones.
death, sudden; defibrillation; genetics; ion channels; tachyarrhythmias; Brugada syndrome; implantable; cardioverter-defibrillator; st-segment-elevation; bundle-branch block; ventricular-fibrillation; risk stratification; sudden-death; leads v-1; individuals; arrhythmias; prognosis; pattern