Synthesis and antimicrobial evaluation of 6-chloroquinolinylhydrazones and acyclonucleosides of 7-chloro-1,2,4-triazolo 4,3-a quinolines | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5174943

Reference Type

Journal Article

Title

Synthesis and antimicrobial evaluation of 6-chloroquinolinylhydrazones and acyclonucleosides of 7-chloro-1,2,4-triazolo 4,3-a quinolines

Author(s)

Hasanen, JA; Ibrahim, EI; Zein, MA; Rezki, N; El-Ashry, EH

Year

2008

Is Peer Reviewed?

Yes

Journal

Journal of the Chemical Society of Pakistan
ISSN: 0253-5106

Publisher

CHEM SOC PAKISTAN

Location

KARACHI

Volume

Issue

Page Numbers

276-284

Language

English

Web of Science Id

WOS:000255847300022

URL

http://://CCC:000255847300022
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Abstract

Condensation of 6-chloro-2-hydrazinoquinoline (1) with monosaccharides 2a-e gave the corresponding sugar hydrazones 3a-e which upon acetylation gave the corresponding acetates 4f-j. Cyclization of 3a-e using iron (III) chloride afforded the acyclic nucleosides of triazoloquinolines 5a-e which were also acetylated to give 6f-j. Compound I was also condensed with aldehydes and isatin to give the corresponding hydrazones 7-10. Reactions of I with ethylchloroformate, phthalic anhydride, acetyl acetone and tosyl chloride were also investigated. All compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria.

Keywords

Chemistry; hepatitis-b-virus, nucleosides, derivatives, analogs, ring