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HERO ID
5176758
Reference Type
Journal Article
Subtype
Review
Title
Recent Structural Insights into Cytochrome P450 Function
Author(s)
Guengerich, FP; Waterman, MR; Egli, M
Year
2016
Is Peer Reviewed?
1
Journal
Trends in Pharmacological Sciences
ISSN:
0165-6147
Volume
37
Issue
8
Page Numbers
625-640
Language
English
PMID
27267697
DOI
10.1016/j.tips.2016.05.006
Abstract
Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic activities are important issues in areas such as drug-drug interactions and endocrine function. During the past 30 years, structures of P450s have been very helpful in understanding function, particularly the mammalian P450 structures available in the past 15 years. We review recent activity in this area, focusing on the past 2 years (2014-2015). Structural work with microbial P450s includes studies related to the biosynthesis of natural products and the use of parasitic and fungal P450 structures as targets for drug discovery. Studies on mammalian P450s include the utilization of information about 'drug-metabolizing' P450s to improve drug development and also to understand the molecular bases of endocrine dysfunction.
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