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5177443 
Journal Article 
Enteric Coatings II**Product Research and Development Dept., The Upjohn Co., Kalamazoo, Mich.: Starch (and Amylose) Acetate Phthalates 
Wagner, JG; Brignall, TW; Long, S 
1959 
48 
244-249 
Eight new whole starch (and amylose) acetate phthalates differing in acetyl and phthalyl contents were prepared by acetylation of a reactive form of starch or amylose with acetic anhydride in the presence of formamide followed by phthalylation of the partial acetates with phthalic anhydride in the presence of pyridine. Solubilities of the compounds indicated they would be useful substances for enteric coating. Tablets were enteric coated with one of the starch acetate phthalates and a commercial cellulose acetate phthalate. In vitro, at pH 6.9, ox bile extract but not pancreatin increased the rate of disintegration of the enteric coated tablets; hence, under these conditions, ionization of free carboxyl groups and not the action of enzymes in pancreatin is mainly responsible for the disintegration of these enteric coated tablets.