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5177483 
Journal Article 
Diastereoselective access to chiral non-racemic 1,3 oxazolo 2,3-a isoindol-5-one ring systems via O-cationic cyclization 
Sikoraiova, J; Chihab-Eddine, A; Marchalin, S; Daich, A 
2002 
Yes 
Journal of Heterocyclic Chemistry
ISSN: 0022-152X 
WILEY 
HOBOKEN 
39 
2 
383-390 
English 
WOS:000175524200023 
The title compounds 4 have been prepared from suitable beta-amino-alcohol 2 and phthalic anhydride (5) in a three-step sequence in moderate to good yields (58-94%). The key step of this methodology is based on an intramolecular O-cationic cyclization involving N-acyliminium. species. The high levels of the observed chemoselectivity during the intermolecular or intramolecular cyclization were also discussed. 
Polymer Science; bicyclic lactams, isoindolin-1-one derivatives, pi-cyclizations, facile,; reactivity, nucleophiles, analogs